monkeybread.calc.ligand_receptor_score

monkeybread.calc.ligand_receptor_score(adata, contacts, lr_pairs)

Calculates scores for ligand-receptor pairs in contacting cells.

Score calculation is as described in [HBB+22].

Parameters

• adata (AnnData) – Annotated data matrix.

• contacts (Dict[str, Set[str]]) – The cell contacts, as calculated by monkeybread.calc.cell_contact().

• lr_pairs (Union[Tuple[str, str], List[Tuple[str, str]]]) – One or multiple tuples corresponding to (ligand, receptor).

Return type

Dict[Tuple[str, str], float]

Returns

A mapping from ligand-receptor tuple pairs to pair scores.